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Biochem Biophys Res Commun. 1999 Mar 24;256(3):603-7.

STAT-1-independent upregulation of FADD and procaspase-3 and -8 in cancer cells treated with cytotoxic drugs.

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1
Department of Biology and Therapy of Cancer (JE 515), Faculty of Medicine and Pharmacy, 7 boulevard Jeanne d'Arc, Dijon CĂ©dex, 21033, France.

Abstract

We have previously shown that treatment by anticancer drugs sensitized tumor cells to Fas (APO-1/CD95)-mediated cell death. The present study demonstrates that the cytotoxic drugs cisplatin, doxorubicin and mitomycin C induce the accumulation of the Fas receptor, the FADD adaptor molecule, the procaspases-8, -3 and -2L and the proapoptotic molecule Bax in several human colon cancer cells. This upregulation is also observed in U3A myeloblastoma cells that do not express STAT-1, a transcription factor involved in the constitutive expression of procaspases. We conclude that anticancer drugs sensitize tumor cells to Fas-mediated cell death by a STAT-1-independent upregulation of molecules involved in this apoptotic pathway.

PMID:
10080945
DOI:
10.1006/bbrc.1999.0391
[Indexed for MEDLINE]

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