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Biochem Biophys Res Commun. 1999 Mar 24;256(3):485-7.

Mycobacterium tuberculosis KatG is a peroxynitritase.

Author information

1
Department of Biochemistry and Molecular Biology and Section of Hematology Research, Mayo Clinic and Foundation, Rochester, Minnesota, 55905, USA.

Abstract

Mycobacterium tuberculosis resides within the highly oxidative environment of the human macrophage and previous reports have indicated that these mycobacteria are susceptible to reactive nitrogen intermediates including peroxynitrite. This work provides evidence that the Mycobacterium tuberculosis hemoprotein KatG acts as an efficient peroxynitritase exhibiting a kapp of 1.4 x 10(5) M-1s-1 for peroxynitrite decomposition at pH 7.4 and 37 degrees C. The ability of KatG to act as a peroxynitritase adds to its growing list of enzymatic activities and may in part explain the ability of Mycobacterium tuberculosis to persist in macrophages.

PMID:
10080924
DOI:
10.1006/bbrc.1999.0358
[Indexed for MEDLINE]

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