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J Clin Immunol. 1999 Jan;19(1):1-11.

Interleukin-18 and interleukin-1 beta: two cytokine substrates for ICE (caspase-1).

Author information

1
Department of Medicine, University of Colorado Health Sciences Center, Denver 80262, USA.

Abstract

This special article deals with the role of processing enzymes in the generation of bioactive cytokines, particularly IL-1 beta and the novel cytokine IL-18, which was formerly called IFN gamma-inducing factor (IGIF). The "classical" pathways of cytokine processing are described, as well as the importance of alternative cleavage enzymes. The topic of this review also concerns the biology of IL-18. The regulation of IL-18 production, the IL-18 receptor complex, and the biological effects of this novel cytokine are described.

PMID:
10080100
DOI:
10.1023/a:1020506300324
[Indexed for MEDLINE]

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