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Dev Genes Evol. 1999 Apr;209(4):260-3.

An amphioxus Msx gene expressed predominantly in the dorsal neural tube.

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School of Animal and Microbial Sciences, The University of Reading, Whiteknights, Reading, RG6 6AJ, UK.


Genomic and cDNA clones of an Msx class homeobox gene were isolated from amphioxus (Branchiostoma floridae). The gene, AmphiMsx, is expressed in the neural plate from late gastrulation; in later embryos it is expressed in dorsal cells of the neural tube, excluding anterior and posterior regions, in an irregular reiterated pattern. There is transient expression in dorsal cells within somites, reminiscent of migrating neural crest cells of vertebrates. In larvae, mRNA is detected in two patches of anterior ectoderm proposed to be placodes. Evolutionary analyses show there is little phylogenetic information in Msx protein sequences; however, it is likely that duplication of Msx genes occurred in the vertebrate lineage.

[Indexed for MEDLINE]

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