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Neurology. 1999 Mar 10;52(4):854-7.

Creatine monohydrate increases strength in patients with neuromuscular disease.

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Department of Neurology/Neurological Rehabilitation and Kinesiology, McMaster University Medical Center, Hamilton, Ontario, Canada.


Creatine monohydrate has been shown to increase strength in studies of young healthy subjects and in a few studies with patients. Creatine monohydrate (10 g daily for 5 days to 5 g daily for 5 days) was administered to patients with neuromuscular disease in a pilot study (Study 1; n = 81), followed by a single-blinded study (Study 2; n = 21). Body weight, handgrip, dorsiflexion, and knee extensor strength were measured before and after treatment. Creatine administration increased all measured indices in both studies. Short-term creatine monohydrate increased high-intensity strength significantly in patients with neuromuscular disease.

[Indexed for MEDLINE]

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