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Int J Radiat Oncol Biol Phys. 1999 Feb 1;43(3):587-90.

Defining the implant treatment volume for patients with low risk prostate cancer: does the anterior base need to be treated?

Author information

1
Joint Center for Radiation Therapy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215, USA. ADAMICO@JCRT.harvard.edu

Abstract

PURPOSE:

An increased incidence of acute urinary retention has been reported after interstitial prostate radiation therapy when the anterior base of the prostate gland receives 100% of the prescription dose. The frequency of prostate cancer in this location as a function of the pre-treatment prostate specific antigen (PSA), biopsy Gleason score, and 1992 American Joint Commission on Cancer Staging (AJCC) was determined.

METHODS AND MATERIALS:

One hundred four men treated at the Brigham and Women's Hospital with radical prostatectomy for clinically localized prostate cancer between 1995-1996 comprised the study population. Prostatectomy specimens were whole mounted and the location of each tumor foci enumerated.

RESULTS:

Of 269 foci of prostate cancer found in 39 low-risk prostate cancer patients (PSA < 10 ng/ml, biopsy Gleason score < or = 6, and 1992 AJCC clinical stage T1c,2a), a single focus (0.37%) was noted in the anterior base. Conversely, 20/355 (5.6%) and 18/251 (7.2%) tumor foci were noted in the anterior base in 43 patients with intermediate risk and 24 patients with high-risk disease, respectively.

CONCLUSIONS:

A new definition of the treatment volume excluding the anterior base for low-risk prostate cancer patients may be justified.

PMID:
10078642
DOI:
10.1016/s0360-3016(98)00434-9
[Indexed for MEDLINE]

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