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Hum Hered. 1999 Mar;49(2):85-9.

Contribution of interleukin 1beta and KM loci to alopecia areata.

Author information

1
Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC 29425-2230, USA.galbragm@musc.edu

Abstract

Alopecia areata is a common skin disease in which proinflammatory cytokines such as IL-1beta may play a pathogenic role. In this study, we examined the distribution of genotypes of an IL-1beta single base change polymorphism at position +3953 in patients with alopecia areata. The distribution of immunoglobulin kappa light chain (KM) genotypes was similarly examined. The data obtained showed that the IL-1beta and KM loci act cooperatively to significantly increase susceptibility to alopecia areata.

PMID:
10077728
DOI:
10.1159/000022850
[Indexed for MEDLINE]

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