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Chem Biol. 1999 Mar;6(3):R65-9.

How Taxol stabilises microtubule structure.

Author information

1
MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK. laa@mrc-lmb.cam.ac.uk

Abstract

The structure of tubulin shows paclitaxel (Taxol(R)) binding to a pocket in beta tubulin on the microtubule's inner surface, which counteracts the effects of GTP hydrolysis occurring on the other side of the monomer.

PMID:
10074470
[Indexed for MEDLINE]
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