Format

Send to

Choose Destination
See comment in PubMed Commons below
Annu Rev Med. 1999;50:303-16.

Allergic bronchopulmonary aspergillosis.

Author information

1
Pulmonary and Critical Care Unit, Massachusetts General Hospital, Boston, USA. cockrill.barbara@mgh.harvard.edu

Abstract

Allergic bronchopulmonary aspergillosis (ABPA) is a syndrome seen in patients with asthma and cystic fibrosis. It is characterized by chronic colonization of the airways with a ubiquitous fungus, Aspergillus fumigatus. The clinical expression of ABPA results from the complex interaction of chronic colonization of the airways with A fumigatus, host factors allowing this colonization, and the host's genetically determined immune response. Clinically the syndrome is characterized by recurrent episodes of wheezing, mucus production, pulmonary infiltrates, and elevated levels of serum IgE. Many patients develop central bronchiectasis, and a subset will go on to endstage fibrotic lung disease. It is thought that treatment will prevent this progression. The mainstay of therapy remains oral corticosteroids.

PMID:
10073280
DOI:
10.1146/annurev.med.50.1.303
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Atypon
    Loading ...
    Support Center