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Zhongguo Yao Li Xue Bao. 1997 Jan;18(1):3-5.

Effect of melittin on ion transport across cell membranes.

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1
Department of Medicine, University of Louisville, KY 40292, USA.

Abstract

Extensive work with melittin has shown that the venom has multiple effects, probably, as a result of its interaction with negatively changed phospholipids. It inhibits well known transport pumps such as the Na(+)-K(+)-ATPase and the H(+)-K(+)-ATPase. Melittin increases the permeability of cell membranes to ions, particularly Na+ and indirectly Ca2+, because of the Na(+)-Ca(2+)-exchange. This effect results in marked morphological and functional changes, particularly in excitable tissues such as cardiac myocytes. In some other tissues, e.g., cornea, not only Na+ but Cl- permeability is also increased by melittin. Similar effects to melittin on H(+)-K(+)-ATPase have been found with the synthetic amphipathic polypeptide Trp-3.

PMID:
10072885
[Indexed for MEDLINE]
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