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Mech Dev. 1999 Feb;80(2):181-4.

Heart specific expression of mouse BMP-10 a novel member of the TGF-beta superfamily.

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1
Genetics Institute Inc., 87 Cambridge Park Drive, Cambridge, MA 02140, USA.

Abstract

Here we report the cloning and expression of murine BMP-10, a novel member of the TGF-beta superfamily. In the mouse embryo, BMP-10 expression begins at 9.0 d.p.c. and is restricted to the developing heart. Initially, BMP-10 expression localizes to the trabeculated part of the common ventricular chamber and to the bulbus cordis region. After 12.5 d.p.c., additional BMP-10 expression is seen in the atrial wall. The data presented here suggest that BMP-10 plays an important role in trabeculation of the embryonic heart.

PMID:
10072785
DOI:
10.1016/s0925-4773(98)00221-4
[Indexed for MEDLINE]
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