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Curr Opin Neurobiol. 1999 Feb;9(1):128-34.

Maternal care and the development of stress responses.

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  • 1Developmental Neuroendocrinology Laboratory Douglas Hospital Research Center Departments of Psychiatry and Neurology & Neurosurgery 6875 Boul LaSalle McGill University MontrĂ©al Canada H4H 1R3.


Studies dating from the 1950s have documented the impact of early life events on the development of behavioral and endocrine responses to stress. Recent findings suggest that these effects are mediated through changes in mother-offspring interactions and have identified central corticotropin-releasing factor systems as a critical target for the effects of variations in maternal care.

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