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Curr Opin Neurobiol. 1999 Feb;9(1):88-93.

Neuronal activity during development: permissive or instructive?

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Division of Neuroscience Program in Developmental Biology Room S-603 Baylor College of Medicine One Baylor Plaza Houston Texas 77030 USA.


Experimental studies over the past year have shown that neural activity has a range of effects on the development of neural pathways. Although activity appears unimportant for establishing many aspects of the gross morphology and topology of the brain, there are many cases where the presence of neural activity is essential for the formation of a mature system of neural connections; in some instances, the pattern of neural activity actually orchestrates the final arrangement of neural connections.

[Indexed for MEDLINE]

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