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Curr Opin Neurobiol. 1999 Feb;9(1):79-87.

Formation of lamina-specific synaptic connections.

Author information

1
Department of Anatomy and Neurobiology Washington University Medical School 660 South Euclid Avenue Campus Box 8108 St Louis Missouri 63110 USA. sanesj@thalamus.wustl.edu

Abstract

In many parts of the vertebrate central nervous system, inputs of distinct types confine their synapses to individual laminae. Such laminar specificity is a major determinant of synaptic specificity. Recent studies of several laminated structures have begun to identify some of the cells (such as guidepost neurons in hippocampus), molecules (such as N-cadherin in optic tectum, semaphorin/collapsin in spinal cord, and ephrins in cerebral cortex), and mechanisms (such as activity-dependent refinement in lateral geniculate) that combine to generate laminar specificity.

PMID:
10072367
DOI:
10.1016/s0959-4388(99)80010-5
[Indexed for MEDLINE]

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