Format

Send to

Choose Destination
Curr Opin Neurobiol. 1999 Feb;9(1):54-64.

Control of muscle fibre and motoneuron diversification.

Author information

1
MRC Muscle and Cell Motility Unit Developmental Biology Research Centre The Randall Institute King's College London 26-29 Drury Lane London WC2B 5RL UK. simon.hughes@kcl.ac.uk

Abstract

Recent studies have elucidated both the mechanism of early formation of diverse muscle fibre types and the matching of diverse populations of motoneurons to their appropriate muscle targets. Highlights include the demonstration that distinct signals are necessary for the formation of several distinct myoblast populations in the vertebrate somite, the identification of motoneuron subtypes, studies of how motoneurons target appropriate muscles, and rapid progress on the Drosophila neuromuscular system. We propose a model in which four classes of decision control the patterning of both motoneurons and muscles.

PMID:
10072365
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center