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Curr Opin Neurobiol. 1999 Feb;9(1):47-53.

Transcriptional control of neurotransmitter phenotype.

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Laboratoire de Génétique et Physiologie du Développement Developmental Biology Institute of Marseille CNRS/INSERM Université de la Méditerranée AP de Marseille Campus de Luminy, Marseille Cedex 9 France.


The specification of neurotransmitter phenotype is an important aspect of neuronal fate determination. Recent studies have begun to define essential transcriptional regulators involved in controlling the mode of neurotransmission in vertebrates and invertebrates, and to examine their regulation by cell-extrinsic factors. An emerging concept is that the control of transmitter choice is intimately linked to that of other aspects of the neuronal phenotype.

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