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Curr Opin Genet Dev. 1999 Feb;9(1):62-8.

The regulation of replication origin activation.

Author information

1
CRC Chromosome Replication Group, Wellcome Trust Building, University of Dundee, Dundee DD1 5EH, UK. adonaldson@bad.dundee.ac.uk

Abstract

At the start of the cell-division programme, proteins must be assembled onto replication origins to establish competence for initiation of DNA synthesis. At the correct moment, other effectors must then coordinate appropriate firing of the various origins to control entry into and progress through S phase. These processes are key targets of cell-cycle control, and understanding their regulation will provide a deeper knowledge of the mechanisms controlling cell proliferation.

PMID:
10072361
DOI:
10.1016/s0959-437x(99)80009-4
[Indexed for MEDLINE]

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