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Curr Opin Genet Dev. 1999 Feb;9(1):112-7.

Ras caught in another affair: the exchange factors for Ral.

Author information

1
Laboratory for Physiological Chemistry, Center for Biomedical Genetics,Stratenum, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands.

Abstract

The Ral guanine nucleotide exchange factors are direct targets of Ras, providing a mechanism for Ral activation by extracellular signals. In addition, Ral can be activated by a Ras-independent pathway. Ral guanine nucleotide exchange factors contribute to cellular transformation induced by oncogenic Ras through an Erk-independent mechanism which may involve activation of transcription.

PMID:
10072355
DOI:
10.1016/s0959-437x(99)80016-1
[Indexed for MEDLINE]

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