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Curr Opin Genet Dev. 1999 Feb;9(1):104-11.

CDK inhibition and cancer therapy.

Author information

1
Onyx Pharmaceuticals, 3031 Research Drive, Richmond, California 94806, USA. mgarrett@onyx-pharm.com

Abstract

The cell-division cycle is a tightly controlled process that is regulated by the cyclin/CDK family of protein kinase complexes. Stringent control of this process is essential to ensure that DNA synthesis and subsequent mitotic division are accurately and coordinately executed. There is now strong evidence that CDKs, their regulators, and substrates are the targets of genetic alteration in many human cancers. As a result of this, the CDKs have been targeted for drug discovery and a number of small molecule inhibitors of CDKs have been identified.

PMID:
10072351
DOI:
10.1016/s0959-437x(99)80015-x
[Indexed for MEDLINE]

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