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Curr Opin Genet Dev. 1999 Feb;9(1):40-8.

Histone acetylases and deacetylases in cell proliferation.

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Wellcome/CRC Institute, Department of Pathology, Tennis Court Road, Cambridge CB2 1QR, UK.


There are several enzymes, acetylases and deacetylases, that can regulate transcription by modifying the acetylation state of histones or other promoter-bound transcription factors. Some of these enzymes are present in multisubunit complexes. Recent efforts to understand the biological role of these enzymes reveals their involvement in cell-cycle regulation and differentiation. Furthermore, accumulating evidence suggests that deregulation of acetylase and deacetylase activity plays a causative role in the generation of cancer.

[Indexed for MEDLINE]

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