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Am J Kidney Dis. 1999 Mar;33(3):555-62.

Thrombotic microangiopathy as a complication of long-term therapy with gemcitabine.

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Memorial Sloan-Kettering Cancer Center and New York Hospital-Cornell University Medical College, NY 10021, USA.


Three patients with pancreatic carcinoma treated with gemcitabine for 1 year developed clinical and laboratory findings compatible with an indolent form of the hemolytic-uremic syndrome. Renal biopsy specimens in two of these patients showed the characteristic features of thrombotic microangiopathy, and a skin biopsy specimen from the third patient, who presented with livedo reticularis, showed intravascular fibrin deposition. Thrombotic microangiopathy may represent a toxic effect of long-term gemcitabine therapy.

[Indexed for MEDLINE]

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