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Br J Cancer. 1999 Feb;79(5-6):940-4.

Immunohistochemical localization of CD1a-positive putative dendritic cells in human breast tumours.

Author information

1
Department of Surgery, University of Adelaide, Royal Adelaide Hospital, Australia.

Abstract

The presence of a high number of infiltrating CD1a+ cells in malignant neoplasms has been reported to be associated with an improved prognosis, reduced tumour recurrence and fewer metastases. This study identified a population of CD1a+ cells within the lymphoid cell infiltrate in human ductal breast carcinoma (n = 52), which was significantly different from normal breast tissue, in which only two out of nine cases expressed CD1a+ cells (P = 0.0192). In the majority of cases, the infiltrate was low compared with the number of macrophages and T cells present (results not shown). There was no correlation between the number of CD1a+ cells and tumour grade, with all tumour grades expressing similar numbers of infiltrating CD1a+ cells. There was clear evidence, however, that the CD1a+ cells were closely associated with tumour cells. It is likely that CD1a+ cells have a role in antigen capture and presentation in human tumours, and this study documents the density of CD1a+ cells in a large sample of all histological grades of human breast carcinomas.

PMID:
10070894
PMCID:
PMC2362664
DOI:
10.1038/sj.bjc.6690150
[Indexed for MEDLINE]
Free PMC Article

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