Format

Send to

Choose Destination
Eye (Lond). 1998;12 ( Pt 5):809-14.

Carbon monoxide poisoning causes optic neuropathy.

Author information

1
Ophthalmology Department, St James' University Hospital, Leeds, UK.

Abstract

PURPOSE:

To describe the electrophysiological and psychophysical effects of carbon monoxide (CO) poisoning on visual function.

METHODS:

Three patients are presented who suffered CO poisoning, two due to suicide attempts and one in the course of a road traffic accident. After a full ocular examination, Goldmann visual fields, flash and pattern visual evoked potentials (VEPs) and flash and pattern electroretinograms (ERGs) were tested.

RESULTS:

Electrophysiology showed reduced or absent N95 components of the pattern ERG and delayed, reduced VEPs. A positive-negative-positive (PNP) VEP waveform was seen in two cases. In one case, where presentation occurred at an early stage, visual and electrophysiological function was improved with hydroxycobalamine.

CONCLUSIONS:

The combination of ERG and VEP findings suggest that CO poisoning can cause a toxic optic neuropathy that may have a similar aetiological mechanism to that in tobacco amblyopia. Early treatment with hydroxycobalamine may be of some benefit.

PMID:
10070515
DOI:
10.1038/eye.1998.209
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center