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Eur J Immunogenet. 1999 Feb;26(1):1-3.

In vitro production of IFN-gamma correlates with CA repeat polymorphism in the human IFN-gamma gene.

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School of Biological Sciences, University of Manchester, UK.


The DNA sequence of the human IFN-gamma gene shows the presence of a variable-length CA repeat in the first intron of the gene. We investigated the allele distribution of this microsatellite region in 164 unrelated healthy individuals, and the association with interferon-gamma (IFN-gamma) production. In vitro production of IFN-gamma showed a significant correlation with the presence of allele #2.

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