The synthesis and antiviral activity of 4-fluoro-1-beta-D-ribofuranosyl-1H-pyrazole-3-carboxamide

R Storer; C J Ashton; A D Baxter; M M Hann; C L Marr; A M Mason; C L Mo; P L Myers; S A Noble; C R Penn; N G Weir; J M Woods; P L Coe

doi:10.1080/15257779908043068

The synthesis and antiviral activity of 4-fluoro-1-beta-D-ribofuranosyl-1H-pyrazole-3-carboxamide

Nucleosides Nucleotides. 1999 Feb;18(2):203-16. doi: 10.1080/15257779908043068.

Authors

R Storer¹, C J Ashton, A D Baxter, M M Hann, C L Marr, A M Mason, C L Mo, P L Myers, S A Noble, C R Penn, N G Weir, J M Woods, P L Coe

Affiliation

¹ GlaxoWellcome Research and Development, Medicines Research Centre, Stevenage, Hertfordshire, UK.

PMID: 10067273
DOI: 10.1080/15257779908043068

Abstract

A novel fluoropyrazole ribonucleoside has been shown to have significant anti-influenza activity in vitro. The compound is compared and contrasted with the structurally-related compound ribavirin in attempts to identify factors having significant bearing on the mode of action of both compounds.

MeSH terms

Antiviral Agents / chemical synthesis*
Antiviral Agents / pharmacology
DNA-Directed RNA Polymerases / antagonists & inhibitors
Enzyme Inhibitors / chemical synthesis
Enzyme Inhibitors / pharmacology
Fluorine Compounds / chemical synthesis
IMP Dehydrogenase / antagonists & inhibitors
Influenza A virus / drug effects
Influenza B virus / drug effects
Intestinal Absorption
Molecular Structure
Nucleosides / chemical synthesis*
Pyrazoles / chemical synthesis
Ribavirin / analogs & derivatives*
Ribavirin / chemical synthesis
Ribose / analogs & derivatives

Substances

4-fluoro-1-ribofuranosyl-1H-pyrazole-3-carboxamide
Antiviral Agents
Enzyme Inhibitors
Fluorine Compounds
Nucleosides
Pyrazoles
Ribavirin
Ribose
IMP Dehydrogenase
DNA-Directed RNA Polymerases