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Curr Opin Plant Biol. 1998 Apr;1(2):142-8.

Position effects and epigenetic silencing of plant transgenes.

Author information

1
Institute of Molecular Biology, Austrian Academy of Sciences, Billrothstrasse 11, A-5020 Salzburg, Austria.

Abstract

Nuclear processes that silence plant transgenes are being revealed by analyses of natural triggers of epigenetic modifications, particularly cytosine methylation, and by comparisons of the genomic environments of differentially expressed transgene loci. It is increasingly apparent that plant genomes can sense and respond to the presence of foreign DNA in certain sequence contexts and at multiple dispersed sites. Determining the basis of this sensitivity and how nuclear defense systems are activated poses major challenges for the future.

PMID:
10066569
DOI:
10.1016/s1369-5266(98)80016-2
[Indexed for MEDLINE]

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