Format

Send to

Choose Destination
Curr Opin Microbiol. 1998 Aug;1(4):455-60.

Roles of cysteine proteinases of trypanosomes and Leishmania in host-parasite interactions.

Author information

1
Wellcome Unit of Molecular Parasitology, University of Glasgow, The Anderson College, Glasgow G11 6NU, Scotland, UK. j.mottram@udcf.gla.ac.uk

Abstract

Trypanosomes and Leishmania contain an abundance of stage-regulated cysteine proteinases encoded by several gene families. Analysis of parasites rendered defective in cysteine proteinase function, either through genetic manipulation or through the use of specific inhibitors, has revealed roles for the enzymes in parasite virulence, in modulation of the host's immune response and in parasite differentiation.

PMID:
10066510
DOI:
10.1016/s1369-5274(98)80065-9
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center