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Behav Pharmacol. 1998 Mar;9(2):179-81.

SR 141716, a CB1 cannabinoid receptor antagonist, selectively reduces sweet food intake in marmoset.

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Sanofi Recherche, Toulouse, France.


SR 141716 (1 and 3 mg/kg p.o.), a selective central (CB1) cannabinoid receptor antagonist, selectively reduced feeding of a very highly palatable cane-sugar mixture in marmosets. In contrast, standard primate pellet intake was not modified at the lower dose, but was slightly increased (+29%;p < 0.01) by the higher dose of SR 141716. These results are in agreement with the hypothesis that endogenous cannabinoid systems are involved in the modulation of the appetitive value of food.

[Indexed for MEDLINE]

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