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Ned Tijdschr Geneeskd. 1998 Dec 26;142(52):2828-30.

[Nobel prize in Medicine and Physiology 1998 for the discovery of the role of nitric oxide as a signalling molecule].

[Article in Dutch]

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Universitair Medisch Centrum, afd. Nefrologie en Interne Geneeskunde, Utrecht.


The Nobel Prize for Medicine and Physiology 1998 was awarded to three American pharmacologists: Robert F.Furchgott, Louis J. Ignarro and Ferrid Murad for their work on nitric oxide as a signalling molecule in the cardiovascular system. This discovery is a classical case of serendipity. NO is an endothelium-derived factor which mediates local vasodilation. It protects the vascular system against atherosclerosis by various effects on leukocytes and vascular permeability. NO appears to be a universal signalling molecule in the body, involved in the inflammatory response, apoptosis and neurotransmission. Its biochemistry is closely linked to that of oxygen radicals.

[Indexed for MEDLINE]

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