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J Pediatr. 1999 Mar;134(3):349-51.

Etidronate therapy for hypercalcemia in subcutaneous fat necrosis of the newborn.

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  • 1Section of Pediatric Endocrinology, Department of Pediatrics, Yale University Medical School, New Haven, Connecticut 06520, USA.


Subcutaneous fat necrosis of the newborn (SCFN) is characterized by indurated violet skin nodules and, occasionally, life-threatening hypercalcemia. Current treatments of patients with SCFN-related hypercalcemia are often only partially successful and may be associated with prolonged hypercalcemia. We now report the use of etidronate, a bisphosphonate, to control hypercalcemia in an infant with SCFN.

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