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J Nutr. 1999 Feb;129(2S Suppl):477S-484S. doi: 10.1093/jn/129.2.477S.

Molecular biology of biotin attachment to proteins.

Author information

1
Department of Microbiology, University of Illinois, Urbana 61801, USA.

Abstract

Enzymatic attachment of biotin to proteins requires the interaction of a distinct domain of the acceptor protein (the "biotin domain") with the enzyme, biotin protein ligase, that catalyzes this essential and rare post-translational modification. Both biotin domains and biotin protein ligases are very strongly conserved throughout biology. This review concerns the protein structures and mechanisms involved in the covalent attachment of biotin to proteins.

PMID:
10064313
DOI:
10.1093/jn/129.2.477S
[Indexed for MEDLINE]

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