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J Neurol Sci. 1999 Jan 1;162(1):102-5.

Manganese intoxication during total parenteral nutrition: report of two cases and review of the literature.

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The Third Department of Internal Medicine, Kagoshima University School of Medicine, Japan.


We report two cases of manganese (Mn) intoxication during total parenteral nutrition including manganese (Mn). Both patients showed parkinsonism with psychiatric symptoms and elevated serum Mn levels. T1-weighted magnetic resonance images (MRI) revealed symmetrical high intensity lesions in the globus pallidus. Discontinuation of Mn supplementation and levodopa treatment improved the symptoms and MRI abnormalities in the both patients. Thus, careful attention should be paid to the long-term intravenous administration of Mn.

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