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Clin Chem. 1999 Mar;45(3):382-7.

Nitrogen dioxide formation during inhaled nitric oxide therapy.

Author information

1
Department of Pediatrics, Indiana University, Indianapolis, IN 46202, USA.gsokol@iupui.edu

Abstract

BACKGROUND:

Nitrogen dioxide (NO2) is a toxic by-product of inhalation therapy with nitric oxide (NO). The rate of NO2 formation during NO therapy is controversial.

METHODS:

The formation of NO2 was studied under dynamic flows emulating a base case NO ventilator mixture containing 80 ppm NO in a 90% oxygen matrix. The difficulty in measuring NO2 concentrations below 2 ppm accurately was overcome by the use of tunable diode laser absorption spectroscopy.

RESULTS:

Using a second-order model, the rate constant, k, for NO2 formation was determined to be (1.19 +/- 0.11) x 10(-11) ppm-2s-1, which is in basic agreement with evaluated data from atmospheric literature.

CONCLUSIONS:

Inhaled NO can be delivered safely in a well-designed, continuous flow neonatal ventilatory circuit, and NO2 formation can be calculated reliably using the rate constant and circuit dwell time.

PMID:
10053039
[Indexed for MEDLINE]
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