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Intern Med. 1999 Jan;38(1):22-6.

Primary biliary cirrhosis associated with membranous glomerulonephritis.

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1
First Department of Internal Medicine, Akita University School of Medicine.

Abstract

A 33-year-old woman was admitted to our department for evaluation of liver dysfunction and proteinuria. A liver biopsy specimen showed ductular proliferation and moderate portal fibrosis indicating stage II primary biliary cirrhosis. A renal biopsy specimen showed mild to moderate mesangial cell proliferation without crescent formation or interstitial nephritis. Immunofluorescent staining revealed deposition of immunoglobulin G (IgG), third component of complement (C3), and Clq on glomerular basement membranes. The findings indicated stage I membranous glomerulonephritis. Administration of ursodesoxycholic acid together with prednisolone, azathioprine, and dipyridamole decreased proteinuria and improved cholestatic liver dysfunction.

PMID:
10052737
DOI:
10.2169/internalmedicine.38.22
[Indexed for MEDLINE]
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