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Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):2082-6.

Interferon-induced human MxA GTPase blocks nuclear import of Thogoto virus nucleocapsids.

Author information

  • 1Abteilung Virologie, Institut für Medizinische Mikrobiologie und Hygiene, Universität Freiburg, D-79008 Freiburg, Germany.

Abstract

Interferon-induced human MxA protein belongs to the dynamin superfamily of large GTPases. It exhibits antiviral activity against a variety of RNA viruses, including Thogoto virus, an influenza virus-like orthomyxovirus transmitted by ticks. Here, we report that MxA blocks the transport of Thogoto virus nucleocapsids into the nucleus, thereby preventing transcription of the viral genome. This interaction can be abolished by a mAb that neutralizes the antiviral activity of MxA. Our results reveal an antiviral mechanism whereby an interferon-induced protein traps the incoming virus and interferes with proper transport of the viral genome to its ultimate target compartment within the infected cell.

PMID:
10051598
PMCID:
PMC26740
[PubMed - indexed for MEDLINE]
Free PMC Article
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