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Intensive Care Med. 1999 Jan;25(1):76-80.

Acute ventilatory restriction in children after weaning off inhaled nitric oxide: relation to rebound pulmonary hypertension.

Author information

1
Abteilung Angeborene Herzfehler, Deutsches Herzzentrum Berlin, Germany. isn@rbh.nthames.nhs.uk

Abstract

OBJECTIVE:

To assess the interaction between pulmonary hemodynamics and respiratory mechanics during acute pulmonary hypertension.

PATIENTS:

Ventilated and paralysed children treated with inhaled nitric oxide because of post-operative pulmonary hypertension.

INTERVENTIONS:

Weaning of inhaled nitric oxide.

MEASUREMENTS:

Air flow and airway pressure, calculation of dynamic respiratory system compliance and respiratory system resistance for each breath by multiple linear regression.

RESULTS:

In four patients, increases in pulmonary arterial pressure from 26.1 to 56.7 mm Hg (p<0.001) during weaning off nitric oxide were associated with decreases in tidal volume (from 9.7-->8.2 ml/kg, p<0.01) and reductions in dynamic respiratory system compliance (from 0.52-->0.34 cm H20/ml/kg, p<0.001), while respiratory system resistance was unchanged.

CONCLUSIONS:

Impaired ventilation during acute pulmonary hypertension is predominantly related to a reduction in respiratory system compliance.

PMID:
10051082
DOI:
10.1007/s001340050790
[Indexed for MEDLINE]

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