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Toxicol Lett. 1998 Nov 23;100-101:89-95.

General anesthetic effects on protein kinase C.

Author information

1
Department of Anesthesiology, Cornell University Medical College, New York, NY 10021, USA. hchemmi@mail.med.cornell.edu

Abstract

(1) Protein kinase C is a family of phospholipid-dependent protein kinases which are involved in the regulation of diverse cellular functions. (2) Evidence is emerging that certain general anesthetics can stimulate the activity of protein kinase C by interacting with the regulatory domain of the enzyme, possibly with the diacylglycerol binding sites. Anesthetics also potentiate activation-dependent down-regulation of the enzyme. (3) A role for PKC in the mediation and or modulation of the cellular effects of general anesthetics is a potential molecular target for anesthetic action.

PMID:
10049186
DOI:
10.1016/s0378-4274(98)00170-2
[Indexed for MEDLINE]

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