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Curr Opin Struct Biol. 1999 Feb;9(1):14-20.

Structure and mechanism in site-specific recombination.

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Department of Biochemistry and Biophysics, Johnson Research Foundation, University of Pennsylvania School of Medicine, 37th and Hamilton Walk, A602 Richards Building, Philadelphia, PA 19104-6089, USA.


Three-dimensional structural information on the integrase family of site-specific recombinases has only recently become available, with the crystal structures of catalytic domains, full-length proteins and protein-DNA complexes of this family reported over the past two years. These results have led to a model for the overall architecture and active site stereochemistry of the recombination pathway that addresses a number of interesting mechanistic issues.

[Indexed for MEDLINE]

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