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Curr Opin Microbiol. 1999 Feb;2(1):30-4.

Cell biology of Legionella pneumophila.

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Department of Molecular Microbiology Washington University School of Medicine 660 S. Euclid Avenue St. Louis MO 63110, USA.


Legionella pneumophila is the causative agent of a potentially fatal form of pneumonia named Legionnaires' disease. L. pneumophila survives and replicates inside macrophages by preventing phagosome-lysosome fusion. A large number of L. pneumophila genes, called dot or icm, have been identified that are required for intracellular growth. It has recently been shown that the dot/icm genes code for a putative large membrane complex that forms a type IV secretion system used to alter the endocytic pathway.

[Indexed for MEDLINE]

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