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Curr Opin Microbiol. 1999 Feb;2(1):35-9.

Molecular and cellular biology of pneumococcal infection.

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Department of Infectious Diseases St Jude Children's Research Hospital 332 N Lauderdale Rd Memphis TN 38105 USA.


The complete pneumococcal genome sequence was released in November, 1997. This advance has been combined with new understanding of physiology and pathogenesis including characterization of a family of surface proteins adducted to choline, regulation of virulence, and the regulon for natural DNA transformation. These developments in our understanding of molecular and cellular biology of pneumococcal infection will allow the development of new vaccines and antibiotics against this community acquired pathogen.

[Indexed for MEDLINE]

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