Format

Send to

Choose Destination
Curr Opin Immunol. 1999 Feb;11(1):19-22.

Recognition of gram-negative bacteria and endotoxin by the innate immune system.

Author information

1
Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA. ulevitch@scripps.edu.

Abstract

Until about 10 years ago the exact mechanisms controlling cellular responses to the endotoxin - or lipopolysaccharide (LPS) - of Gram-negative bacteria were unknown. Now a considerable body of evidence supports a model where LPS or LPS-containing particles (including intact bacteria) form complexes with a serum protein known as LPS-binding protein; the LPS in this complex is subsequently transferred to another protein which binds LPS, CD14. The latter is found on the plasma membrane of most cell types of the myeloid lineage as well as in the serum in its soluble form; LPS binding to these two forms of CD14 results in the activation of cell types of myeloid and nonmyeloid lineages, respectively.

PMID:
10047547
DOI:
10.1016/s0952-7915(99)80004-1
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center