Format

Send to

Choose Destination
Curr Opin Immunol. 1999 Feb;11(1):13-8.

The Toll-receptor family and control of innate immunity.

Author information

1
Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.

Abstract

Innate immune recognition is mediated by a system of germline-encoded receptors that recognize conserved molecular patterns that are associated with microbial pathogens. These receptors are coupled to signal transduction pathways that control expression of a variety of inducible immune-response genes. Toll receptors and the associated signaling pathways of nuclear factor kappaB may represent the most ancient host defense system found in mammals, insects and plants.

PMID:
10047546
DOI:
10.1016/s0952-7915(99)80003-x
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center