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Curr Opin Immunol. 1999 Feb;11(1):47-52.

Phagocytosis and development: back to the future.

Author information

1
Laboratory of Developmental Immunology and Cutaneous Biology Research Center, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

Abstract

Removal of apoptotic cells and micro-organisms is mediated via phagocytosis. Phagocytes express pattern-recognition receptors (PRRs) that recognize apoptotic-cell-associated membrane patterns (ACAMPs). Similar ACAMPs and PRRs are used by mammals, Caenorhabditis elegans and Drosophila melanogaster. Some PRRs recognize apoptotic cells and micro-organisms, suggesting overlap between these functions.

PMID:
10047544
DOI:
10.1016/s0952-7915(99)80009-0
[Indexed for MEDLINE]

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