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Curr Opin Immunol. 1999 Feb;11(1):82-8.

Genes regulating MHC class I processing of antigen.

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INSERM U25 Hôpital Necker, Paris, France.


The principal pathway of antigen processing that is associated with MHC class I involves three main steps: cytosolic peptide generation, peptide transport into the endoplasmic reticulum and peptide assembly with class I molecules. Recent advances suggest that additional cytosolic proteases complement the proteasome as a source of antigenic peptides. Peptide assembly involves several novel cofactors - including the proteins tapasin and ERp57, which may be important for stabilisation of empty class I molecules as well as quality control after peptide binding. Finally, genetic evidence suggests an important influence of an unidentified gene, in the MHC complex, on MHC class I processing.

[Indexed for MEDLINE]

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