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Curr Opin Cell Biol. 1999 Feb;11(1):26-33.

Molecular mechanisms of nonmuscle myosin-II regulation.

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Department of Biochemistry Albert Einstein College of Medicine 1300 Morris Park Avenue Bronx NY 10461 USA.


Myosin II, the conventional two-headed myosin that forms bipolar filaments, is directly involved in regulating cytokinesis, cell motility and cell morphology in nonmuscle cells. To understand the mechanisms by which nonmuscle myosin-II regulates these processes, investigators are now looking at the regulation of this molecule in vertebrate nonmuscle cells. The identification of multiple isoforms of nonmuscle myosin-II, whose activities and regulation differ from that of smooth muscle myosin-II, suggests that, in addition to regulatory light chain phosphorylation, other regulatory mechanisms control vertebrate nonmuscle myosin-II activity.

[Indexed for MEDLINE]

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