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Curr Opin Cell Biol. 1999 Feb;11(1):134-41.

Accessory protein regulation of microtubule dynamics throughout the cell cycle.

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Department of Biological Sciences 111 Research Drive Lehigh University Bethlehem PA 18015 USA.


A number of accessory proteins capable of stabilizing or destabilizing microtubule polymers in dividing cells have been identified recently. Many of these accessory proteins are modified and regulated by cell-cycle-dependent phosphorylation. Through this regulation, microtubule dynamics are modified to generate rapid microtubule turnover during mitosis. In general, although some microtubule-stabilizing proteins are inactivated at entry into mitosis, a critical balance between microtubule stabilizers and destabilizers is necessary for assembly of the mitotic spindle.

[Indexed for MEDLINE]

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