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Curr Opin Biotechnol. 1999 Feb;10(1):87-93.

Phage-display technology--finding a needle in a vast molecular haystack.

Author information

1
Institute of Molecular Biophysics Florida State University Tallahassee Florida 32306 USA.

Abstract

Screening of phage-displayed libraries of proteins and peptides has, for nearly a decade, proven to be a highly effective method for finding much needed 'needles' in a vast molecular 'haystack'. Over the past year, it has been used to solve an increasing diversity of problems, including identification of binding motifs for much smaller targets and the use of novel screening methods to identify chemical activities.

PMID:
10047512
DOI:
10.1016/s0958-1669(99)80016-0
[Indexed for MEDLINE]

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