Format

Send to

Choose Destination
See comment in PubMed Commons below
BMJ. 1999 Feb 27;318(7183):559-62.

Risk of testicular cancer in subfertile men: case-control study.

Author information

1
Centre for Research in Health and Social Statistics, Danish National Research Foundation, Sejrogade 11, DK-2100 Copenhagen O, Denmark.

Abstract

OBJECTIVE:

To evaluate the association between subfertility in men and the subsequent risk of testicular cancer.

DESIGN:

Population based case-control study.

SETTING:

The Danish population.

PARTICIPANTS:

Cases were identified in the Danish Cancer Registry; controls were randomly selected from the Danish population with the computerised Danish Central Population Register. Men were interviewed by telephone; 514 men with cancer and 720 controls participated.

OUTCOME MEASURE:

Occurrence of testicular cancer.

RESULTS:

A reduced risk of testicular cancer was associated with paternity (relative risk 0.63; 95% confidence interval 0.47 to 0.85). In men who before the diagnosis of testicular cancer had a lower number of children than expected on the basis of their age, the relative risk was 1.98 (1.43 to 2.75). There was no corresponding protective effect associated with a higher number of children than expected. The associations were similar for seminoma and non-seminoma and were not influenced by adjustment for potential confounding factors.

CONCLUSION:

These data are consistent with the hypothesis that male subfertility and testicular cancer share important aetiological factors.

PMID:
10037628
PMCID:
PMC27753
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Support Center