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Epidemiol Infect. 1998 Dec;121(3):599-608.

P fimbriae and other adhesins enhance intestinal persistence of Escherichia coli in early infancy.

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1
Department of Clinical Immunology, Göteborg University, Sweden.

Abstract

Resident and transient Escherichia coli strains were identified in the rectal flora of 22 Pakistani infants followed from birth to 6 months of age. All strains were tested for O-antigen expression, adhesin specificity (P fimbriae, other mannose-resistant adhesins or type 1 fimbriae) and adherence to the colonic cell line HT-29. Resident strains displayed higher mannose-resistant adherence to HT-29 cells, and expressed P fimbriae (P = 0.0036) as well as other mannose-resistant adhesins (P = 0.012) more often than transient strains. In strains acquired during the first month of life, P fimbriae were 12 times more frequent in resident than in transient strains (P = 0.0006). The O-antigen distribution did not differ between resident and transient strains, and none of the resident P-fimbriated strains belonged to previously recognized uropathogenic clones. The results suggest that adhesins mediating adherence to intestinal epithelial cells, especially P fimbriae, enhance the persistence of E. coli in the large intestine of infants.

PMID:
10030709
PMCID:
PMC2809567
DOI:
10.1017/s0950268898001137
[Indexed for MEDLINE]
Free PMC Article

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