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Mutat Res. 1999 Jan 25;423(1-2):73-7.

Stabilization of the intermediate in frameshift mutation.

Author information

1
Department of Molecular Genetics and Cell Biology, The University of Chicago, 920 E. 58th Street, Chicago, IL 60637, USA.

Abstract

A mismatch repair, proofreading deficient mutant of Escherichia coli lost a C from a C8 run at a rate 10 times higher than the loss of A from an A8 sequence in the same double mutant. This greater frameshift instability of a homopolymeric run of C's may be due to stabilization of a stacked intermediate. Gain of a (CA) unit in a similarly constructed (CA)15 sequence occurred at a rate about 1/3 that previously reported for a (CA)14 construct losing a (CA) repeat unit.

PMID:
10029680
DOI:
10.1016/s0027-5107(98)00227-9
[Indexed for MEDLINE]

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